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Tipping the balance: targeting the thymus for production of immune cells protective against Auto-Immune Disease

McCarthy, Nick (2015) Tipping the balance: targeting the thymus for production of immune cells protective against Auto-Immune Disease. In: University of Birmingham Graduate School Research Poster Conference 2015, 16th June 2015, University of Birmingham. (Unpublished)

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The thymus is the unique site of production of T-cells, an essential arm of the adaptive immune system which is targeted by vaccinations as a defense against infectious diseases. In generating a potent cohort of pathogen- clearing T-cells, small numbers of cells capable of attacking tissues within the body are also produced. Under normal conditions these are kept in check by “regulatory” cells, however if the balance of “auto-immune” and regulatory cells is altered, it has the potential to trigger auto-immune diseases, such as rheumatoid arthritis and diabetes.

Using mouse models, we aim to investigate the potential to manipulate thymic production of anti-inflammatory T-cells to aid treatment of auto-immune disease.

Type of Work:Conference or Workshop Item (Poster)
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:School of Biomedical Science
Date:June 2015
Series/Collection Name:Prizewinners from the Graduate School Research Poster Conference 2015
Subjects:R Medicine > R Medicine (General)
Related URLs:
Copyright Status:This poster is copyright of the author and/or third parties. The intellectual property rights in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this poster must be in accordance with that legislation and must be properly acknowledged.
Copyright Holders:The Author
ID Code:2114

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