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Pro-B1X: the creator of bone

Lewis, Jonathan W. (2019) Pro-B1X: the creator of bone. In: University of Birmingham Graduate School Research Poster Conference 2019, 19th June 2019, University of Birmingham 2019. (Unpublished)

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As we age, natural changes in bone and muscle occur. However, sometimes these changes can lead to diseases such as rheumatoid arthritis (RA) and osteoporosis. In the past 50 years there have been big improvements in the treatment of RA, leading to a large increase in life expectancy. However, new treatments are being developed at a slow pace and treatment strategies predominantly modify only minor features of the diseases and are not able to stop or reverse bone damage. Recently we have found a novel leukocyte transmigration peptide, agent X, which may have the ability to increase bone growth, leading to stronger, less breakable bones.
Additionally, in models of disease, preliminary data has suggested that agent X is able to restore bone growth and decrease bone damage. This data advocates that in both healthy and diseased bones, agent X may have a beneficial strengthening role, providing possible therapeutic potential in reducing fracture rates in the elderly and restoring bone growth during arthritis.

Type of Work:Conference or Workshop Item (Poster)
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:Institute of Inflammation and Ageing
Additional Information:

College of Medical and Dental Sciences Winner. Supervisors: Amy Naylor, Helen M. McGettrick (University of Birmingham) & James R. Edwards (University of Oxford)

Date:19 June 2019
Series/Collection Name:Prizewinners from the Graduate School Research Poster Conference 2019
Subjects:Q Science > QM Human anatomy
R Medicine > R Medicine (General)
Related URLs:
Copyright Status:This poster is copyright of the author and/or third parties. The intellectual property rights in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this poster must be in accordance with that legislation and must be properly acknowledged.
Copyright Holders:The Author
ID Code:3238

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